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Probenecid sodium

Cat. No. M10535
Probenecid sodium Structure
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1g USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

Probenecid sodium is a sodium salt of Probenecid that is soluble in water. Probenecid (Benemid) is an organic anionic transport competitive inhibitor, as well as an agonist of transient receptor potential vanillin receptor subfamily 2(TRPV2) and an inhibitor of human bitter taste receptor TAS2R16.

Chemical Information
Molecular Weight 307.34
Formula C13H18NNaO4S
CAS Number 23795-03-1
Solubility (25°C) Water
Storage 2-8°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tetsuya Taniguchi, et al. Sci Rep. Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2

[2] Masato Kobayashi, et al. Nucl Med Biol. Assessment of drug transporters involved in the urinary secretion of [ 99m Tc]dimercaptosuccinic acid

[3] Stephanie N Liu, et al. CPT Pharmacometrics Syst Pharmacol. Probenecid-Boosted Tenofovir: A Physiologically-Based Pharmacokinetic Model-Informed Strategy for On-Demand HIV Preexposure Prophylaxis

[4] D Jimnez-Gallo, et al. Actas Dermosifiliogr. Calcinosis Cutis and Calciphylaxis

[5] F G MARSON. Ann Rheum Dis. Sodium salicylate and probenecid in the treatment of chronic gout; assessment of their relative effects in lowering serum uric acid levels

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