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Pristinamycin

Cat. No. M6131

Pristinamycin Structure
Size Price Availability Quantity
5mg USD 250 In stock
10mg USD 450 In stock
25mg USD 1000 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

The pristinamycins exhibit a strong synergistic antibacterial activity against a wide range of Gram-positive and some Gram-negative bacteria, including methicillin- and vancomycin-resistant strains. Pristinamycin is an effective, well-tolerated alternative therapeutic option in MSSA BJI, on condition that a daily dosage of 50 mg/kg is respected.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 866.96
Formula C45H54N8O10
CAS Number 270076-60-3
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Pristinamycin in the treatment of MSSA bone and joint infection.
Valour F, et al. J Antimicrob Chemother. 2016 Apr;71(4):1063-70. PMID: 26801082.

A Complex Signaling Cascade Governs Pristinamycin Biosynthesis in Streptomyces pristinaespiralis.
Mast Y, et al. Appl Environ Microbiol. 2015 Oct;81(19):6621-36. PMID: 26187956.

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  Catalog
Abmole Inhibitor Catalog 2017




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