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Pratensein

Cat. No. M9942
Pratensein Structure
Synonym:

5,7,3'-Trihydroxy-4'-methoxyisoflavone

Size Price Availability
5mg USD 700  USD700 4-7 Days
10mg USD 1050  USD1050 4-7 Days
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Biological Activity

Pratensein

Chemical Information
Molecular Weight 300.26
Formula C16H12O6
CAS Number 2284-31-3
Solubility (25°C) Soluble in Methanol
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rui Wang, et al. Pratensein Mitigates Oxidative Stress and NLRP3 Inflammasome Activation in OGD/R-Injured HT22 Cells by Activating Nrf2-Anti-oxidant Signaling

[2] Ling Wei, et al. Corrigendum to "Pratensein attenuates Aβ-induced cognitive deficits in rats: Enhancement of synaptic plasticity and cholinergic function" [Fitoterapia 101 (2015) 208-217]

[3] Mandana Behbahani. Anti-human immunodeficiency virus-1 activities of pratensein and pratensein glycoside from Alhaji maurorum and its parasite Cuscuta kotchiana

[4] Chunhong Liang, et al. Pratensein ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels

[5] Ling Wei, et al. Pratensein attenuates Aβ-induced cognitive deficits in rats: enhancement of synaptic plasticity and cholinergic function

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Keywords: Pratensein, 5,7,3'-Trihydroxy-4'-methoxyisoflavone supplier, Others, inhibitors, activators

 
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