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Ponesimod

Cat. No. M5886
Ponesimod Structure
Synonym:

ACT-128800

Size Price Availability Quantity
5mg USD 100  USD100 In stock
10mg USD 165  USD165 In stock
50mg USD 520  USD520 In stock
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Quality Control & Documentation
Biological Activity

Ponesimod(ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM.

Chemical Information
Molecular Weight 460.97
Formula C23H25ClN2O4S
CAS Number 854107-55-4
Solubility (25°C) 90 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Olsson T, et al. J Neurol Neurosurg Psychiatry. Oral ponesimod in relapsing-remitting multiple sclerosis: a randomised phase II trial.

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  Catalog
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Keywords: Ponesimod, ACT-128800 supplier, S1P Receptor, inhibitors, activators


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