Polyethylenimine is a surfactant that acts as a polyelectrolyte multilayer on a charged surface, providing that surface with a biocompatible coat. Polyethylenimine (PEI) is a hydrophilic cationic polymer widely used as a nonviral nucleotide delivery reagent.
Polyethyleneimine can be used as a non-viral synthetic polymer vector for in vivo delivery of therapeutic nucleic acids. The interaction between negatively charged nucleic acids and positively charged polymer backbone results in the formation of nano-sized complexes. This neutralized complex protects the enclosed nucleic acid from enzymes and maintains its stability till the cellular uptake takes place. For example, human serum albumin conjugated PEI shows good pDNA transfection and low toxicity.
PEI can be used to functionalize single-walled nanotubes (SWNTs) to improve their solubility and biocompatibility while maintaining the structural integrity of the original SWNT. Covalently functionalized SWNTs find application in CO2 absorption and gene delivery.
| Molecular Weight | 600 |
| Formula | H(NHCH2CH2)nNH2 |
| CAS Number | 9002-98-6 |
| Form | viscous liquid |
| Solubility (25°C) | miscible with water and ethylene glycol soluble in ethanol |
| Storage | RT, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Yu Zou, et al. Macromol Biosci. Polyethylenimine-Based Nanogels for Biomedical Applications
[5] Barbara Demeneix, et al. Adv Genet. Polyethylenimine (PEI)
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