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Polyethylenimine Linear (MW 40000)

Cat. No. M21453
Polyethylenimine Linear (MW 40000) Structure
Size Price Availability Quantity
250mg USD 200  USD200 In stock
1g USD 480  USD480 In stock
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Quality Control & Documentation
Biological Activity

Polyethylenimine Linear (PEI)  is a cationic polymer with a molecular weight of 40,000 that forms a compound with nucleic acid and passes it into mammalian cells. Linear PEI transfection reagents are widely suitable.

Chemical Information
Molecular Weight 40000
Formula (CH2CH2NH)N
CAS Number 49553-93-7
Form Solid
Storage 2-8°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jie Wang, et al. Viruses. The 40 kDa Linear Polyethylenimine Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection by Blocking Its Attachment to Permissive Cells

[2] Jason T Rodier, et al. J Ocul Pharmacol Ther. Linear Polyethylenimine-DNA Nanoconstruct for Corneal Gene Delivery

[3] Han Zhou, et al. Mol Med Rep. Linear polyethylenimine-plasmid DNA nanoparticles are ototoxic to the cultured sensory epithelium of neonatal mice

[4] Daniel K Bonner, et al. J Control Release. Crosslinked linear polyethylenimine enhances delivery of DNA to the cytoplasm

[5] Paola Vicennati, et al. Curr Med Chem. Polyethylenimine in medicinal chemistry

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Polyethylenimine, Linear (MW 25000)

Polyethylenimine Linear (PEI) solution consists of a cationic polymer transfection reagent with a molecular weight of 25,000, which forms a complex with nucleic acids and allows the complex to enter mammalian cells. In addition, Polyethylenimine Linear is one of the most commonly used reagents in small to large scale transfection.

Polyethylenimine, Linear (MW 25000, liquid)

Polyethylenimine Linear (PEI) solution consists of a cationic polymer transfection reagent with a molecular weight of 25,000, which forms a complex with nucleic acids and allows the complex to enter mammalian cells.

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