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PNPP disodium

Cat. No. M9399
PNPP disodium Structure
Size Price Availability Quantity
1g USD 50  USD50 In stock
5g USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

PNPP (Para-nitrophenyl phosphate) disodium is a non-proteinaceous chromogenic substrate for alkaline and acid phosphatases used in ELISA and conventional spectrophotometric assays.

Chemical Information
Molecular Weight 263.05
Formula C6H4NNa2O6P
CAS Number 4264-83-9
Form Solid
Solubility (25°C) Water ≥ 100 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Carolina Nunes da Silva, et al. The synthetic peptide PnPP-19 potentiates erectile function via nNOS and iNOS

[2] Carolina Nunes da Silva, et al. PnPP-19 Peptide as a Novel Drug Candidate for Topical Glaucoma Therapy Through Nitric Oxide Release

[3] Carolina Nunes da Silva, et al. PnPP-19 Peptide Restores Erectile Function in Hypertensive and Diabetic Animals Through Intravenous and Topical Administration

[4] A C N Freitas, et al. PnPP-19, a spider toxin peptide, induces peripheral antinociception through opioid and cannabinoid receptors and inhibition of neutral endopeptidase

[5] Carolina Nunes Silva, et al. PnPP-19, a Synthetic and Nontoxic Peptide Designed from a Phoneutria nigriventer Toxin, Potentiates Erectile Function via NO/cGMP

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