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Pirodavir

Cat. No. M3711
Pirodavir Structure
Synonym:

R77975

Size Price Availability Quantity
2mg USD 180  USD180 In stock
5mg USD 250  USD250 In stock
10mg USD 350  USD350 In stock
50mg USD 930  USD930 In stock
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Quality Control & Documentation
Biological Activity

Pirodavir (R77975) is a capsid - bound anti-picornavirus compound that is active in vitro against most rhinovirus (RV) serotypes.

Chemical Information
Molecular Weight 369.46
Formula C21H27N3O3
CAS Number 124436-59-5
Solubility (25°C) DMSO 67 mg/mL
Ethanol 7 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hayden FG, et al. Antimicrob Agents Chemother. Intranasal pirodavir (R77,975) treatment of rhinovirus colds.

[2] Hayden FG, et al. Antimicrob Agents Chemother. Safety and efficacy of intranasal pirodavir (R77975) in experimental rhinovirus infection.

[3] Andries K, et al. Antimicrob Agents Chemother. In vitro activity of pirodavir (R 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity.

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