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Pipecolic acid

Cat. No. M15074
Pipecolic acid Structure
Synonym:

piperidine-2-carboxylic acid

Size Price Availability Quantity
200mg USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

Pipecolic acid, a lysine metabolite, is an important immunomodulator in plants and humans.

Chemical Information
Molecular Weight 129.16
Formula C6H11NO2
CAS Number 535-75-1
Solubility (25°C) Water ≥ 40 mg/mL
Storage RT, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lennart Mohnike, et al. Plant Cell. The glycosyltransferase UGT76B1 modulates N-hydroxy-pipecolic acid homeostasis and plant immunity

[2] Keshun Yu, et al. Bio Protoc. Pipecolic Acid Quantification Using Gas Chromatography-coupled Mass Spectrometry

[3] Yeong-Hoon Han, et al. Enzyme Microb Technol. Enhancement of pipecolic acid production by the expression of multiple lysine cyclodeaminase in the Escherichia coli whole-cell system

[4] Asako Shigemura, et al. J Poult Sci. Intracerebroventricular Injection of L-Pipecolic Acid Exerts Hypnotic Effects Without Activating NMDA Receptors in Neonatal Chicks under Social Isolation-induced Stress

[5] Min He. J Ind Microbiol Biotechnol. Pipecolic acid in microbes: biosynthetic routes and enzymes

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