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PIK-293

Cat. No. M3450
PIK-293 Structure
Size Price Availability
5mg USD 140 Custom Synthesis
10mg USD 260 Custom Synthesis
50mg USD 780 Custom Synthesis
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

PIK-293 is a PI3-K inhibitor. PIK-293 inhibit the p110α, p110β, p110δ, and p110γ with IC50 of 100uM,25μM,0.24μM,and 10μM.PIK-293 is the parent compand of PIK-294.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 397.43
Formula C22H19N7O
CAS Number 900185-01-5
Purity >99%
Solubility DMSO 70 mg/mL
Storage at -20°C
Related PI3K Products
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IPI-3063 is a potent and selective p110δ inhibitor with biochemical IC50 of 2.5 ± 1.2 nM and IC50 values for the other class I PI3K isoforms (p110α, p110β, p110γ) are at least 400-fold higher.

GDC-0084

GDC-0084 is a brain penetrant inhibitor of PI3K and mTOR.

GNE-317

GNE-317 is a potent, brain-penetrant PI3K inhibitor.

Serabelisib

Serabelisib (INK-1117,MLN-1117,TAK-117) is a potent and selective oral PI3Kα isoform inhibitor (IC50 of 21 nmol/L against PI3Kα) that has demonstrated > 100-fold selectivity relative to other class I PI3K family members (PI3Kβ/γ/δ) and mTOR, and a high degree of selectivity against many other kinase.

SF2523

SF2523 is a highly selective and potent inhibitor of PI3K with IC50 values of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PIK-293 supplier, PI3K, inhibitors

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