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PI 828

Cat. No. M7139
PI 828 Structure
Size Price Availability Quantity
5mg USD 330  USD330 In stock
10mg USD 560  USD560 In stock
25mg USD 1100  USD1100 In stock
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Quality Control & Documentation
Biological Activity

PI 828 is a pI 3-Kinase inhibitor (IC50 values are 0.098, 0.183, 0.227 and 1.967 μM for p110β, p110α, p110δ and p110γ respectively) that displays higher potency than LY 294002. Can be immobilized onto a solid phase.

Chemical Information
Molecular Weight 322.36
Formula C19H18N2O3
CAS Number 942289-87-4
Solubility (25°C) DMSO 32.24 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dent, et al. FEBS Lett. Characterization of PAF receptors on human neutrophils using the specific antagonist, WEB 2086.

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