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PI-3065

Cat. No. M5337
PI-3065 Structure
Size Price Availability Quantity
5mg USD 100 In stock
10mg USD 165 In stock
50mg USD 500 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

PI-3065 is a novel potent and selective PI3K p110δ inhibitor with IC50 of 15 nM; exhibits > 100 fold selectivity against p110α, p110β, p110γ, DNA-PK and mTOR

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 506.64
Formula C27H31FN6OS
CAS Number 955977-50-1
Purity >99%
Solubility 10mM in DMSO
Storage at -20°C
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PI 828

PI 828 is a pI 3-kinase inhibitor, more potent than LY 294002.

IPI3063

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GDC-0084

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PI-3065 supplier, PI3K, inhibitors

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