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Phytohemagglutinin

Cat. No. M9333
Phytohemagglutinin Structure
Synonym:

PHA

Size Price Availability Quantity
5mg USD 70  USD70 In stock
10mg USD 130  USD130 In stock
25mg USD 230  USD230 In stock
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Quality Control & Documentation
Biological Activity

Phytohemagglutinin (PHA) induces apoptosis via increasing proapoptotic protein Bax and activating caspases-3.

Chemical Information
CAS Number 9008-97-3
Solubility (25°C) Water ≥ 10 mg/mL
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kochubei TO, et al. Exp Oncol. Isolectins of phytohemagglutinin are able to induce apoptosis in HEp-2 carcinoma cells in vitro.

[2] Movafagh A, et al. Iran J Pharm Res. The Significance Application of Indigenous Phytohemagglutinin (PHA) Mitogen on Metaphase and Cell Culture Procedure.

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Keywords: Phytohemagglutinin, PHA supplier, inhibitors, activators


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