Physcion is an anthraquinone from roots of Rheum officinale Baill.
Sci Rep. 2020 Oct 7;10(1):16769.
The effects of fructose and metabolic inhibition on hepatocellular carcinoma
Physcion purchased from AbMole
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Source | Microbiol Res (2014). Figure 5. Physcion |
| Method | Western blot | |
| Cell Lines | HeLa cells | |
| Concentrations | 1–10 μM | |
| Incubation Time | 24 h | |
| Results | According to the western blot analysis, the activities of caspase-3 and -9 were increased by treatment with physcion in a dose-dependent manner |
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Source | Microbiol Res (2014). Figure 2. Physcion |
| Method | FACS analysis | |
| Cell Lines | HeLa cells | |
| Concentrations | 50 and 100 μM | |
| Incubation Time | 24 h | |
| Results | According to Fig. 2(a), the isolated secondary metabolite, physcion has shown cytotoxic and antiproliferative effects in HeLa cells. |
| Cell Experiment | |
|---|---|
| Cell lines | HeLa cells |
| Preparation method | HeLa cells were cultured in 96-well plates at a density of 5 × 103 cells/well. After 24 h, cells were washed with fresh medium and were treated with different concentrations of physcion. After the next 24 h of incubation, cells were washed two times with phosphate buffered saline (PBS) and 100 μl of MTT solution (1 mg/ml) was added to each well. |
| Concentrations | 1–10 μM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | male nude mice |
| Formulation | |
| Dosages | 40 mg and 20 mg/kg/day |
| Administration | i.p. |
| Molecular Weight | 284.26 |
| Formula | C16H12O5 |
| CAS Number | 521-61-9 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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