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Photochlor

Cat. No. M9038
Photochlor Structure
Synonym:

HPPH

Size Price Availability Quantity
5mg USD 200  USD200 In stock
10mg USD 320  USD320 In stock
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Quality Control & Documentation
Biological Activity

Photochlor is a second generation photosensitizer, which acts as a photodynamic therapy (PDT) agent. The cellular uptake of GO-PEG-HPPH and HPPH is investigated with 4T1 murine mammary cancer cells. The cells are incubated with GO-PEG-HPPH and free Photochlor at equivalent Photochlor concentration (1 µM) for 24 h and then observed with a confocal microscope. Upon intravenous administration, HPPH selectively accumulates in the cytoplasm of cancer or pre-cancerous cells. When laser light is applied, a photodynamic reaction between HPPH and oxygen occurs, resulting in the production of cytotoxic free radicals and singlet oxygen and free radical-mediated cell death. Compared to the first-generation photosensitizer porfimer sodium, HPPH shows improved pharmacokinetic properties and causes only mild skin photosensitivity which declines rapidly within a few days after administration.

Chemical Information
Molecular Weight 636.82
Formula C39H48N4O4
CAS Number 149402-51-7
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rong P, et al. Theranostics. Photosensitizer loaded nano-graphene for multimodality imaging guided tumor photodynamic therapy.

[2] Sun G, et al. Lasers Surg Med. Synergistic effects of photodynamic therapy with HPPH and gemcitabine in pancreatic cancer cell lines.

[3] Nava HR, et al. Lasers Surg Med. Photodynamic therapy (PDT) using HPPH for the treatment of precancerous lesions associated with Barrett's esophagus.

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Keywords: Photochlor, HPPH supplier, inhibitors, activators


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