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Phenytoin Sodium

Cat. No. M5876
Phenytoin Sodium Structure
Synonym:

Diphenylhydantoin Sodium

Size Price Availability Quantity
100mg USD 60 In stock
500mg USD 90 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Phenytoin Sodium is an inactive voltage-gated sodium channel stabilizer.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 274.25
Formula C15H11N2NaO2
CAS Number 630-93-3
Purity >99%
Solubility 32 mg/mL in DMSO
Storage at -20°C
References

Melatonin attenuates phenytoin sodium-induced DNA damage.
Erenberk U, et al. Drug Chem Toxicol. 2014 Apr;37(2):233-9. PMID: 24171672.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Phenytoin Sodium, Diphenylhydantoin Sodium supplier, Sodium Channel, inhibitors

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