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Phenylephrine

Cat. No. M10684
Phenylephrine  Structure
Synonym:

去氧肾上腺素; (R)-(-)-Phenylephrine; L-Phenylephrine

Size Price Availability Quantity
500mg USD 60  USD60 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

(R)-(-)-Phenylephrine is a selective α1- adrenergic receptor agonists, mainly used as decongestants.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 167.21
Formula C9H13NO2
CAS Number 59-42-7
Purity >99%
Solubility DMSO ≥ 20 mg/mL
Storage at -20°C
References

[1] Sandra Larson, et al. JBI Evid Synth. Effect of phenylephrine on cerebral oxygen saturation and cardiac output in adults when used to treat intraoperative hypotension: a systematic review

[2] Hartley C Atkinson, et al. Eur J Clin Pharmacol. Potential cardiovascular adverse events when phenylephrine is combined with paracetamol: simulation and narrative review

[3] M Macmillan, et al. Eur J Anaesthesiol. Phenylephrine toxicity

[4] R G Pearl. Anesthesiology. Phenylephrine and inhaled nitric oxide in adult respiratory distress syndrome. When are two better than one?

[5] S M Burns, et al. Crit Care Nurse. Phenylephrine

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Keywords: Phenylephrine , 去氧肾上腺素; (R)-(-)-Phenylephrine; L-Phenylephrine supplier, Adrenergic Receptor, inhibitors

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