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PFI 4

Cat. No. M5064
PFI 4 Structure
Size Price Availability Quantity
10mM*1mL In DMSO USD 80 In stock
5mg USD 70 In stock
10mg USD 100 In stock
50mg USD 380 In stock
100mg USD 650 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

PFI-4 is cell permeable, and acts by displacing the BRPF1 bromodomain from Histone H3.3.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 380.44
Formula C21H24N4O3
CAS Number 900305-37-5
Purity >98%
Solubility DMSO 17 mg/mL warmed
Storage at -20°C
References

1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain.
Demont EH,et.al. ACS Med Chem Lett. 2014 Sep 10;1190-5. PMID: 25408830.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PFI 4 supplier, Epigenetic Reader Domain, inhibitors

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