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PFE-360

Cat. No. M10452
PFE-360 Structure
Synonym:

PF-06685360; PFE360

Size Price Availability Quantity
2mg USD 220  USD220 In stock
5mg USD 330  USD330 In stock
10mg USD 490  USD490 In stock
50mg USD 1220  USD1220 In stock
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Quality Control & Documentation
Biological Activity

PFE-360, also known as PF-06685360, is a potent and selective, brain penetrated inhibitor of LRRK2 kinase. PFE-360 (PF-06685360) has a mean IC50 of 2.3 nM in vivo.

Chemical Information
Molecular Weight 308.34
Formula C16H16N6O
CAS Number 1527475-61-1
Solubility (25°C) DMSO 7 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Michael Aagaard Andersen, et al. Neurobiol Dis. Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation

[2] Michael Aagaard Andersen, et al. Toxicology. PFE-360-induced LRRK2 inhibition induces reversible, non-adverse renal changes in rats

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  Catalog
Abmole Inhibitor Catalog




Keywords: PFE-360, PF-06685360; PFE360 supplier, LRRK2, inhibitors, activators


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