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PF-562771

Cat. No. M3778
PF-562771 Structure
Synonym:

AP23848

Size Price Availability
5mg USD 120 Custom Synthesis
10mg USD 180 Custom Synthesis
50mg USD 560 Custom Synthesis
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

AP23464 and PF-562771 (AP23848) potently and selectively target activation-loop mutants of Kit in vitro and in vivo and could have therapeutic potential against D816V-expressing malignancies. Src/Abl inhibitors are compatible with imatinib and suggest that combined Abl inhibitor therapy is a feasible treatment strategy for patients with CML.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 531.63
Formula C30H38N5O2P
CAS Number 834894-21-2
Purity >99%
Solubility DMSO
Storage at -20°C
References

Combined Abl inhibitor therapy for minimizing drug resistance in chronic myeloid leukemia: Src/Abl inhibitors are compatible with imatinib.
O'Hare T, et al. Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6987-93. PMID: 16203792.

In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit.
Corbin AS, et al. Blood. 2005 Jul 1;106(1):227-34. PMID: 15746079.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PF-562771, AP23848 supplier, Src-bcr-Abl, inhibitors

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