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PF-431396

Cat. No. M5334

PF-431396 Structure
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

In A20 cells, PF-431396 blocks anti-Ig- and clustering LFA-1-induced tyrosine phosphorylation of Pyk2 and FAK, and further blocks B cell spreading. PF-431396 consistently inhibits the increase in protein tyrosine phosphorylation (PY) induced by the absence of added calcium and induced by W-7 in the presence of calcium.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 506.5
Formula C22H21F3N6O3S
CAS Number 717906-29-1
Purity >98%
Solubility 100 mg/mL in DMSO
Storage at -20°C
Chemical Name
References

A role for the tyrosine kinase Pyk2 in depolarization-induced contraction of vascular smooth muscle.
Mills RD, et al. J Biol Chem. 2015 Apr 3;290(14):8677-92. PMID: 25713079.

NADPH oxidase/ROS-dependent PYK2 activation is involved in TNF-α-induced matrix metalloproteinase-9 expression in rat heart-derived H9c2 cells.
Yang CM, et al. Toxicol Appl Pharmacol. 2013 Oct 15;272(2):431-42. PMID: 23774252.

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  Catalog
Abmole Inhibitor Catalog 2015




Keywords: PF-431396 supplier, FAK, inhibitors

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