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PF-07321332 (Nirmatrelvir)

Cat. No. M10594
PF-07321332 (Nirmatrelvir) Structure
Synonym:

Nirmatrelvir; PF07321332; PF-7321332

Size Price Availability Quantity
5mg USD 320  USD320 In stock
10mg USD 560  USD560 In stock
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Quality Control
Biological Activity

PF-07321332 (Nirmatrelvir) is an orally bioavailable 3C-like protease (3CLPRO) inhibitor with an ki of 3.11 nM. PF-07321332 binds directly to the catalytic cysteine (Cys145) residue of the enzyme. 3CLPRO is responsible for cleaving polyproteins 1a and 1ab of SARS-CoV-2. PF-07321332 is an oral COVID-19 antiviral clinical candidate. By inhibiting the main protease, PF-07321332 prevents the virus from cleaving long protein chains into the parts it needs to reproduce itself.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 499.53
Formula C23H32F3N5O4
CAS Number 2628280-40-8
Purity 99.37%
Solubility DMSO ≥ 90 mg/mL
Storage at -20°C
References

[1] Koen Vandyck, et al. Curr Opin Virol. Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PF-07321332 (Nirmatrelvir), Nirmatrelvir; PF07321332; PF-7321332 supplier, Anti-infection, inhibitors

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