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PF-06726304

Cat. No. M11245
PF-06726304  Structure
Synonym:

PF-6726304

Size Price Availability Quantity
10mg USD 150  USD150 In stock
25mg USD 350  USD350 In stock
50mg USD 640  USD640 In stock
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Quality Control & Documentation
Biological Activity

Pf-06726304 is an effective selective EZH2 inhibitor. Pf-06726304 inhibited wild type and Y641N mutant EZH2 with Ki of 0.7 and 3.0 nM, respectively. Pf-06726304 has strong anti-tumor growth activity.

Chemical Information
Molecular Weight 446.33
Formula C22H21Cl2N3O3
CAS Number 1616287-82-1
Solubility (25°C) DMSO ≥ 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Marjo J den Broeder, et al. Epigenetics Chromatin. Inhibition of methyltransferase activity of enhancer of zeste 2 leads to enhanced lipid accumulation and altered chromatin status in zebrafish

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  Catalog
Abmole Inhibitor Catalog




Keywords: PF-06726304 , PF-6726304 supplier, Histone Methyltransferase, inhibitors, activators


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