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Pexmetinib (ARRY-614)

Cat. No. M5873
Pexmetinib (ARRY-614) Structure
Size Price Availability Quantity
5mg USD 110 In stock
10mg USD 190 In stock
50mg USD 590 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Pexmetinib (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 556.63
Formula C31H33FN6O3
CAS Number 945614-12-0
Purity >98%
Solubility 100 mg/mL in DMSO
Storage at -20°C
References

A phase I study of oral ARRY-614, a p38 MAPK/Tie2 dual inhibitor, in patients with low or intermediate-1 risk myelodysplastic syndromes.
Garcia-Manero G, et al. Clin Cancer Res. 2015 Mar 1;21(5):985-94. PMID: 25480830.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Pexmetinib (ARRY-614) supplier, p38 MAPK, inhibitors

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