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Peretinoin

Cat. No. M13397
Peretinoin Structure
Synonym:

NIK333

Size Price Availability
2mg USD 160  USD160 4-7 Days
5mg USD 260  USD260 4-7 Days
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Quality Control & Documentation
Biological Activity

Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with EC50 of 9 μM. Peretinoin (10-40 μM; 12-72 hours) exhibits suppressed the mRNA level of sphingosine kinase 1 (SPHK1) expression after 24 h treatment, even at 10 μM and more prominent after 72 h peretinoin treatment. Peretinoin (5 μM; 24 hours) up-regulates the expression of LC3B-II and increases autophagy flux in mouse primary hepatocytes.

Chemical Information
Molecular Weight 302.45
Formula C20H30O2
CAS Number 81485-25-8
Solubility (25°C) DMSO 45 mg/mL
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hyun Young Woo, et al. Molecules. Peretinoin, an Acyclic Retinoid, for the Secondary Prevention of Hepatocellular Carcinoma

[2] Kazuhisa Murai, et al. Int J Mol Sci. Peretinoin, an Acyclic Retinoid, Inhibits Hepatitis B Virus Replication by Suppressing Sphingosine Metabolic Pathway In Vitro

[3] Masaya Funaki, et al. Sci Rep. Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo

[4] Chee-Kiat Tan. Expert Rev Gastroenterol Hepatol. Peretinoin as an adjuvant therapy for hepatocellular carcinoma

[5] Kiwamu Okita, et al. J Gastroenterol. Peretinoin after curative therapy of hepatitis C-related hepatocellular carcinoma: a randomized double-blind placebo-controlled study

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