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Pemetrexed Disodium Hydrate

Cat. No. M5866
Pemetrexed Disodium Hydrate Structure
Synonym:

Pemetrexed sodium hydrate

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in Water USD 56  USD56 In stock
50mg USD 34  USD34 In stock
100mg USD 52  USD52 In stock
500mg USD 134  USD134 In stock
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Quality Control & Documentation
Biological Activity

Pemetrexed Disodium Hydrate is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.

Chemical Information
Molecular Weight 516.42
Formula C20H21N5O6.5/2H2O.2Na
CAS Number 357166-30-4
Solubility (25°C) Water ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Michalak O, et al. Molecules. New Polymorphic Forms of Pemetrexed Diacid and Their Use for the Preparation of Pharmaceutically Pure Amorphous and Hemipentahydrate Forms of Pemetrexed Disodium.

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Keywords: Pemetrexed Disodium Hydrate, Pemetrexed sodium hydrate supplier, Antifolate, inhibitors, activators


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