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PD173955

Cat. No. M2917
PD173955 Structure
Size Price Availability Quantity
5mg USD 180 In stock
10mg USD 285 In stock
25mg USD 550 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

PD173955 is a potent Bcr-Abl inhibitor with IC50 of 1-2 nM, also inhibiting Src activity with IC50 of 22 nM.

Customer Product Validations & Biological Datas
Source Vascul Pharmacol (2013). Figure 1. PD173955
Method western blot
Cell Lines HAECs
Concentrations 5 μM
Incubation Time 30 min
Results PD173955 and PP2 suppressed PLC-induced increase in eNOS phosphorylation and activity.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 443.35
Formula C21H16Cl2N4OS
CAS Number 260415-63-2
Purity >98%
Solubility DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PD173955 supplier, Src-bcr-Abl, inhibitors

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