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BMS202

Cat. No. M5144
BMS202 Structure
Synonym:

PD-1/PD-L1 inhibitor 2

Size Price Availability Quantity
5mg USD 105 In stock
10mg USD 190 In stock
50mg USD 660 In stock
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Quality Control
Biological Activity

PD1-PDL1 inhibitor 2 is a inhibitor of the PD-1 (Programmed death- 1) /PD-L1 (Programmed death-ligand 1) protein/protein interaction. BMS-202 binds to and induces dimerization of PD-L1, an inhibitory immune checkpoint protein. Blockade of the PD-1/PD-Ll ligation using antibodies to PD-Ll has been shown to restore and augment T cell activation in many systems.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 419.52
Formula C25H29N3O3
CAS Number 1675203-84-5
Purity 99.63%
Solubility DMSO: ≥ 40 mg/mL
Storage at -20°C
References

Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2.
Zak KM, et al. Structure. 2017 Aug 1;25(8):1163-1174. PMID: 28768162.

Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).
Zak KM, et al. Oncotarget. 2016 May 24;7(21):30323-35. PMID: 27083005.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BMS202, PD-1/PD-L1 inhibitor 2 supplier, PD-1/PD-L1, inhibitors

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