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Pazopanib HCl (GW786034 )

Cat. No. M5863

Pazopanib HCl (GW786034 ) Structure
Size Price Availability Quantity
10mg USD 60 In stock
50mg USD 120 In stock
100mg USD 180 In stock
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Quality Control
Biological Activity

Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 473.98
Formula C21H23N7O2S.HCl
CAS Number 635702-64-6
Purity >99%
Solubility 17 mg/mL in DMSO
Storage at -20°C
References

Pazopanib versus sunitinib in metastatic renal-cell carcinoma.
Motzer RJ, et al. N Engl J Med. 2013 Aug 22;369(8):722-31. PMID: 23964934.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Pazopanib HCl (GW786034 ) supplier, VEGFR/PDGFR, inhibitors

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