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PAR-4 Agonist Peptide, amide TFA

Cat. No. M14049
PAR-4 Agonist Peptide, amide TFA Structure
Synonym:

PAR-4-AP TFA; AY-NH2 TFA

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Biological Activity

PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

Chemical Information
Molecular Weight 794.82
CAS Number 1228078-65-6
Solubility (25°C) DMSO ≥ 150 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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PAR-4 Agonist Peptide, amide

PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

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Keywords: PAR-4 Agonist Peptide, amide TFA, PAR-4-AP TFA; AY-NH2 TFA supplier, PAR, inhibitors, activators


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