Social recognition ability of adult male rats pre-treated sufficiently long with Oxiracetam is resistant to the neurotoxicity effect of TMT. Oxiracetam administered at doses of 3, 10 and 30 mg/kg immediately after the acquisition session prevented the scopolamine induced prolongation of the transfer latency. Thus, oxiracetam forestalled the impairment of retrieval of memory trace: the animals were able to remember the spatial configuration of the plus-maze. On the contrary, oxiracetam was not effective in the diazepam treated mice. We suggest that beneficial effect of oxiracetam might be confounded or blocked by the anxiolytic effect of diazepam. Oxiracetam interacted with the glutamatergic NMDA receptor system and forestalled the impairment of retrieval of long-term memory. The results also justify the usage of the elevated plus-maze method in the evaluation of potential anti-amnesic or nootropic drugs. Several studies suggest that the substance is safe even when high doses are consumed for a long period of time.
|Animal models||BALB/c mice|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Protective effect of oxiracetam on traumatic brain injury in rats.
Li JW, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013 Jul;29(4):298-300. PMID: 24175546.
Oxiracetam pre- but not post-treatment prevented social recognition deficits produced with trimethyltin in rats.
Hlinák Z, et al. Behav Brain Res. 2005 Jun 20;161(2):213-9. PMID: 15922047.
Oxiracetam prevented the scopolamine but not the diazepam induced memory deficits in mice.
Hlinák Z, et al. Behav Brain Res. 2002 Jul 18;133(2):395-9. PMID: 12110475.
Oxiracetam prevents the MK-801 induced amnesia for the elevated plus-maze in mice.
Hlinák Z, et al. Behav Brain Res. 2000 Dec 20;117(1-2):147-51. PMID: 11099768.
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