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Oxazine 1 perchlorate

Cat. No. M13797
Oxazine 1 perchlorate Structure
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Biological Activity

Oxazine 1 perchlorate is a symmetric cationic dye (λex=653 nm, λem=666 nm).

Chemical Information
Molecular Weight 423.89
CAS Number 24796-94-9
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sarah J Bucknell, et al. J Med Chem. Structure-Based Drug Discovery of N-(( R)-3-(7-Methyl-1 H-indazol-5-yl)-1-oxo-1-((( S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3- d][1,3]oxazine]-1-carbox䲧璵Ỵ璶㧀璴羹癦璤桸ܷŞܷ �癨嶁癤Ѐ瑖冚䀹䲠ࢩܷ èࢩ彿军奋军巫军偌ࢩ恄ࢩ彿军怸ࢩ

[2] Christina Kjr, et al. Phys Chem Chem Phys. Luminescence spectroscopy of oxazine dye cations isolated in vacuo

[3] Petra Krlov, et al. ACS Comb Sci. Polymer-Supported Syntheses of Heterocycles Bearing Oxazine and Thiazine Scaffolds

[4] Maria R M de Brito, et al. Toxicol In Vitro. Cyclohexene-fused 1,3-oxazines with selective antibacterial and antiparasitic action and low cytotoxic effects

[5] Yun-Yan Kuang, et al. Acta Crystallogr C. 3-Bromomethyl-3-ethyl-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[2,1-c][1,4]oxazine-1,4-dione

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