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Ospemifene

Cat. No. M3652
Ospemifene Structure
Synonym:

FC-1271a

Size Price Availability Quantity
10mg USD 60  USD60 In stock
50mg USD 105  USD105 In stock
100mg USD 150  USD150 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Ospemifene produces significant improvements in the structure of the vagina and its pH, and significantly reduces dyspareunia, the main complaint of the women treated. Ospemifene has less carcinogenic potential than tamoxifen. Ospemifene has an agonist action on bone and reduces the growth of all breast cancer models in animal studies, providing they expressed estrogen receptor-α.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 378.89
Formula C24H23ClO2
CAS Number 128607-22-7
Purity >98%
Solubility DMSO
Storage at -20°C
References

[1] Paton DM. Drugs Today (Barc). Ospemifene for the treatment of dyspareunia in postmenopausal women.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ospemifene, FC-1271a supplier, Estrogen Receptor, inhibitors

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