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Ospemifene

Cat. No. M3652
Ospemifene Structure
Synonym:

FC-1271a

Size Price Availability Quantity
10mg USD 60  USD60 In stock
50mg USD 90  USD90 In stock
100mg USD 115  USD115 In stock
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Quality Control & Documentation
Biological Activity

Ospemifene produces significant improvements in the structure of the vagina and its pH, and significantly reduces dyspareunia, the main complaint of the women treated. Ospemifene has less carcinogenic potential than tamoxifen. Ospemifene has an agonist action on bone and reduces the growth of all breast cancer models in animal studies, providing they expressed estrogen receptor-α.

Chemical Information
Molecular Weight 378.89
Formula C24H23ClO2
CAS Number 128607-22-7
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Paton DM. Drugs Today (Barc). Ospemifene for the treatment of dyspareunia in postmenopausal women.

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Keywords: Ospemifene, FC-1271a supplier, Estrogen Receptor, inhibitors, activators


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