Free shipping on all orders over $ 500

Ospemifene

Cat. No. M3652
Ospemifene Structure
Synonym:

FC-1271a

Size Price Availability Quantity
10mg USD 54  USD60 In stock
50mg USD 94.5  USD105 In stock
100mg USD 135  USD150 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Ospemifene produces significant improvements in the structure of the vagina and its pH, and significantly reduces dyspareunia, the main complaint of the women treated. Ospemifene has less carcinogenic potential than tamoxifen. Ospemifene has an agonist action on bone and reduces the growth of all breast cancer models in animal studies, providing they expressed estrogen receptor-α.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 378.89
Formula C24H23ClO2
CAS Number 128607-22-7
Purity >98%
Solubility DMSO
Storage at -20°C
References

Ospemifene for the treatment of dyspareunia in postmenopausal women.
Paton DM. Drugs Today (Barc). 2014 May;50(5):357-64. PMID: 24918836.

Related Estrogen Receptor Products
27-Hydroxycholesterol

27-Hydroxycholesterol is a selective estrogen receptor modulator, and it is also an agonist of the liver X receptor.

SAR439859 (Amcenestrant)

SAR439859 (Amcenestrant) is an orally active, nonsteroidal and selective degrader of estrogen receptor, it is also a potent antagonist of ER with EC50 of 0.2 nM for ERα degradation.

4-Hydroxytamoxifen

4-Hydroxytamoxifen is a selective estrogen receptor modulator.

Methylpiperidino pyrazole

Methylpiperidino pyrazole (MPP) is an agonist for estrogen receptor α and lacks any ligand functionality with estrogen receptor (ER)β.

Endoxifen E-isomer hydrochloride

Endoxifen E-isomer hydrochloride is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM).

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ospemifene, FC-1271a supplier, Estrogen Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.