Free shipping on all orders over $ 500

Oseltamivir

Cat. No. M1959
Oseltamivir Structure
Synonym:

Tamiflu

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 90 In stock
200mg USD 150 In stock
1g USD 345 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Oseltamivir (trade name Tamiflu) is an ethyl ester prodrug of Ro 64-0802, a neuraminidase inhibitor, serving as a competitive inhibitor of the activity of the viral neuraminidase (NA) enzyme upon sialic acid, found on glycoproteins on the surface of normal host cells. By blocking the activity of the enzyme, oseltamivir prevents new viral particles from being released by infected cells. Oral administration of oseltamivir delivers the active antiviral Ro 64-0802 to the bloodstream, and thus all sites of influenza infection (lung, nasal mucosa, middle ear) are accessible. Oseltamivir (Tamiflu) was the first orally active neuraminidase inhibitor commercially developed. Treatment with oseltamivir does not seem to adversely affect the primary in vivo cellular immune responses to influenza virus infection.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 312.4
Formula C16H28N2O4
CAS Number 196618-13-0
Purity 100.00%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C
References

Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants.
Collins PJ, et al. Nature. 2008 Jun 26;453(7199):1258-61. PMID: 18480754.

Clinical pharmacokinetics of the prodrug oseltamivir and its active metabolite Ro 64-0802.
He G, et al. Clin Pharmacokinet. 1999 Dec;37(6):471-84. PMID: 10628898.

Related Anti-infection Products
Cefazolin

Cefazolin is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis.

Vancomycin

Vancomycin is an antibiotic for the treatment of bacterial infections.

Nourseothricin sulfate

Nourseothricin is a broad-spectrum antibiotic derived from Streptomyces noursei.

Targocil

Targocil is a bacteriostatic inhibitor of wall teichoic acid (WTA) biosynthesis, with MIC90s of 2 μg/ mL for both MRSA and MSSA.

Amenamevir

Amenamevir is a herpes virus helicase-primase inhibitor, with an EC50 of 14 ng/mL against HSVs.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Oseltamivir, Tamiflu supplier, Anti-infection, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.