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Cat. No. M1959
Oseltamivir Structure


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Free Sample (0.5-1 mg)  USD 0 In stock
200mg USD 180 In stock
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Quality Control
Biological Activity

Oseltamivir (trade name Tamiflu) is an ethyl ester prodrug of Ro 64-0802, a neuraminidase inhibitor, serving as a competitive inhibitor of the activity of the viral neuraminidase (NA) enzyme upon sialic acid, found on glycoproteins on the surface of normal host cells. By blocking the activity of the enzyme, oseltamivir prevents new viral particles from being released by infected cells. Oral administration of oseltamivir delivers the active antiviral Ro 64-0802 to the bloodstream, and thus all sites of influenza infection (lung, nasal mucosa, middle ear) are accessible. Oseltamivir (Tamiflu) was the first orally active neuraminidase inhibitor commercially developed. Treatment with oseltamivir does not seem to adversely affect the primary in vivo cellular immune responses to influenza virus infection.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 312.4
Formula C16H28N2O4
CAS Number 196618-13-0
Purity 100.00%
Storage at -20°C

Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants.
Collins PJ, et al. Nature. 2008 Jun 26;453(7199):1258-61. PMID: 18480754.

Clinical pharmacokinetics of the prodrug oseltamivir and its active metabolite Ro 64-0802.
He G, et al. Clin Pharmacokinet. 1999 Dec;37(6):471-84. PMID: 10628898.

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Keywords: Oseltamivir, Tamiflu supplier, Anti-infection, inhibitors

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