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Oroxin-A

Cat. No. M4461
Oroxin-A Structure
Size Price Availability Quantity
5mg USD 99  USD99 In stock
10mg USD 160  USD160 In stock
20mg USD 270  USD270 In stock
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Quality Control & Documentation
Biological Activity

Oroxin-A is extracted from Oroxylum indicum.

Chemical Information
Molecular Weight 432.38
Formula C21H20O10
CAS Number 57396-78-8
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rui Feng, et al. A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS

[2] Zhishu Zeng, et al. Host-guest interaction of cucurbit[8]uril with oroxin A and its effect on the properties of oroxin A

[3] Wenlong Sun, et al. Oroxin A from Oroxylum indicum prevents the progression from prediabetes to diabetes in streptozotocin and high-fat diet induced mice

[4] Jun He, et al. Oroxin A inhibits breast cancer cell growth by inducing robust endoplasmic reticulum stress and senescence

[5] Haijun Chen, et al. Development of a Concise Synthetic Approach to Access Oroxin A

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