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Ornidazole

Cat. No. M2900
Ornidazole Structure
Synonym:

Ro 7-0207

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 30  USD30 In stock
100mg USD 35  USD35 In stock
500mg USD 45  USD45 In stock
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Quality Control & Documentation
Biological Activity

Ornidazole is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria.

Chemical Information
Molecular Weight 219.63
Formula C7H10ClN3O3
CAS Number 16773-42-5
Solubility (25°C) DMSO 40 mg/mL
Water 2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rong Tang, et al. Ornidazole-Induced Recurrent Encephalopathy in a Chinese Man: A Rare Case Report and Literature Review

[2] Nikhil Bush, et al. Ofloxacin-ornidazole fixed-dose combination medication-induced pancreatitis with positive rechallenge

[3] Selma Emre, et al. Ornidazole-induced fixed drug reaction on sole: case report and review of the literature

[4] Galip Ersz, et al. Ornidazole-induced autoimmune hepatitis

[5] Sener Barut, et al. Ornidazole-induced hepatitis

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