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Ondansetron Hydrochloride Dihydrate

Cat. No. M5835
Ondansetron Hydrochloride Dihydrate Structure
Synonym:

GR 38032; SN 307; NSC 665799

Size Price Availability Quantity
10mg USD 55 In stock
50mg USD 80 In stock
100mg USD 110 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist (Ki=6.16 nM), with low affinity for dopamine receptors.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 365.85
Formula C18H19N3O.HCl.2H2O
CAS Number 103639-04-9
Purity >98%
Solubility 73 mg/mL warmed in DMSO
Storage at -20°C
References

Ondansetron and the risk of cardiac arrhythmias: a systematic review and postmarketing analysis.
Freedman SB, et al. Ann Emerg Med. 2014 Jul;64(1):19-25. PMID: 24314899.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ondansetron Hydrochloride Dihydrate, GR 38032; SN 307; NSC 665799 supplier, 5-HT Receptor, inhibitors

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