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Olodaterol

Cat. No. M5245
Olodaterol Structure
Synonym:

Striverdi Respimat

Size Price Availability Quantity
2mg USD 120 In stock
5mg USD 240 In stock
10mg USD 350 In stock
25mg USD 700 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Olodaterol (BI1744) is a long acting β2-adrenoceptor agonist with an EC50 of 1.4±0.08 nM.

In Vitro: Olodaterol shows a potent, nearly full agonistic response at the hβ2-adrenoceptor (EC50=0.1 nM; intrinsic activity=88% compared with isoprenaline) and a significant selectivity profile (241- and 2299-fold against the hβ1- and hβ3-ARs, respectively).

In Vivo: Olodaterol is a long acting β2-agonist that induces bronchodilation up to 24 h after dosing in patients with chronic obstructive pulmonary disease (COPD) . Olodaterol dose-dependently attenuates cell influx and pro-inflammatory mediator release in murine and guinea pig models of pulmonary inflammation. Once-daily olodaterol 5 μg is an effective therapy in improving lung function and symptomatic outcomes in patients with moderate to very severe (COPD) receiving other maintenance therapy, with a satisfactory safety profile.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 370.44
Formula C21H26N2O5
CAS Number 868049-49-4
Purity >99%
Solubility 10mM in DMSO
Storage at -20°C
References

Olodaterol for the treatment of chronic obstructive pulmonary disease.
Ramadan WH, et al. Am J Health Syst Pharm. 2016 Aug 1;73(15):1135-43. PMID: 27354040.

The long-acting β2 -adrenoceptor agonist olodaterol attenuates pulmonary inflammation.
Wex E, et al. Br J Pharmacol. 2015 Jul;172(14):3537-47. PMID: 25824824.

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Keywords: Olodaterol, Striverdi Respimat supplier, BACE, inhibitors

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