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Oleic acid (Liquid)

Cat. No. M10449
Oleic acid (Liquid) Structure
Synonym:

9-cis-Octadecenoic acid

Size Price Availability Quantity
1mL USD 100  USD100 In stock
5mL USD 200  USD200 In stock
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Biological Activity

Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid. Oleic acid is also a Na+/K+ ATPase activator. Oleic acid prompts cell proliferation and migration in high metastatic cancer cells via enhancing β-oxidation mediated by AMPK activation. Oleic acid inhibits cancer cell growth and survival in low metastatic carcinoma cells, such as gastric carcinoma SGC7901 and breast carcinoma MCF-7 cell lines.

Chemical Information
Molecular Weight 282.46
Formula C18H34O2
CAS Number 112-80-1
Solubility (25°C) DMSO ≥ 50 mg/mL
Ethanol 80 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shuai Li, et al. PLoS One. High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner

[2] M G Jack-Hays, et al. Biochim Biophys Acta. Activation of Na+/K(+)-ATPase by fatty acids, acylglycerols, and related amphiphiles: structure-activity relationship

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