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Oleanolic Acid

Cat. No. M11298
Oleanolic Acid Structure
Synonym:

Oleanic acid; Caryophyllin

Size Price Availability Quantity
100mg USD 45  USD45 In stock
500mg USD 195  USD195 In stock
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Quality Control & Documentation
Biological Activity

Oleanolic Acid (Oleanic Acid) is a natural compound with anticancer activity, widely distributed in edible and medicinal plants. It is related to betulinic Acid and has relatively non-toxic, anti-tumor, hepatoprotective and antiviral properties.

Chemical Information
Molecular Weight 456.7
Formula C30H48O3
CAS Number 508-02-1
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jos M Castellano, et al. Nutrients. Oleanolic Acid: Extraction, Characterization and Biological Activity

[2] Antonio Sureda, et al. Curr Mol Pharmacol. Hypotensive Effects of the Triterpene Oleanolic Acid for Cardiovascular Prevention

[3] Taiwo Betty Ayeleso, et al. Molecules. Oleanolic Acid and Its Derivatives: Biological Activities and Therapeutic Potential in Chronic Diseases

[4] Chao Lin, et al. Expert Opin Ther Pat. Oleanolic acid derivatives for pharmaceutical use: a patent review

[5] Jacob Pollier, et al. Phytochemistry. Oleanolic acid

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Keywords: Oleanolic Acid, Oleanic acid; Caryophyllin supplier, Autophagy, inhibitors, activators


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