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Octenidine Dihydrochloride

Cat. No. M20907
Octenidine Dihydrochloride Structure
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Quality Control & Documentation
Biological Activity

Octenidine, a cationic surfactant, is active against gram-positive and gram-negative bacteria.

Chemical Information
Molecular Weight 623.83
Formula C36H64Cl2N4
CAS Number 70775-75-6
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jianhua Huang, et al. J Wound Care. Octenidine dihydrochloride treatment of a meticillin-resistant Staphylococcus aureus biofilm-infected mouse wound

[2] Axel Kramer, et al. Skin Pharmacol Physiol. Consensus on Wound Antisepsis: Update 2018

[3] Ojan Assadian. J Wound Care. Octenidine dihydrochloride: chemical characteristics and antimicrobial properties

[4] Georg Daeschlein. Int Wound J. Antimicrobial and antiseptic strategies in wound management

[5] N-O Hbner, et al. Skin Pharmacol Physiol. Octenidine dihydrochloride, a modern antiseptic for skin, mucous membranes and wounds

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