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NVP-ACC789

Cat. No. M9161
NVP-ACC789 Structure
Synonym:

ACC-789; ZK-202650

Size Price Availability Quantity
10mM*1mL USD 108  USD120 In stock
5mg USD 96.3  USD107 In stock
10mg USD 132.3  USD147 In stock
25mg USD 265.5  USD295 In stock
50mg USD 400.5  USD445 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

NVP-ACC789, also known as ACC-789 and ZK-202650, is a potent, selective and orally active inhibitor of the VEGF receptor tyrosine kinases with potential anticancer activity. NVP-ACC789 reduces BME cell number to baseline levels from 1 μM. NVP-ACC789 also completely inhibits VEGF-induced BME and BAE cell invasion and VEGF-C-induced BAE cell invasion. The inhibition is dose-dependent in both cell types with a maximal effect from 1 μM. 

In Vivo, NVP-ACC789 oral doses for 6 days blocks VEGF-induced angiogenesis in a dose-dependent manner.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 405.29
Formula C21H17BrN4
CAS Number 300842-64-2
Purity >98%
Solubility DMSO: ≥ 47 mg/mL (Need ultrasonic and warming)
Storage at -20°C
References

Vascular endothelial growth factor (VEGF) receptor-2 antagonists inhibit VEGF- and basic fibroblast growth factor-induced angiogenesis in vivo and in vitro.
Tille JC, et al. J Pharmacol Exp Ther. 2001 Dec;299(3):1073-85. PMID: 11714897.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: NVP-ACC789, ACC-789; ZK-202650 supplier, VEGFR/PDGFR, inhibitors

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