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NSC23766 trihydrochloride

Cat. No. M2889
NSC23766 trihydrochloride Structure

NSC23766 3HCl salt

Size Price Availability Quantity
5mg USD 55 In stock
10mg USD 97 In stock
50mg USD 415 In stock
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Biological Activity

NSC23766 3HCl is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM; does not inhibit the closely related targets, Cdc42 or RhoA.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 530.96
Formula C24H35N7.3HCl
CAS Number 1177865-17-6
Purity 99.76%
Solubility Water: ≥ 25 mg/mL
Storage at -20°C
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EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1, equally potent inhibition for Rac3.

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Keywords: NSC23766 trihydrochloride, NSC23766 3HCl salt supplier, GTPase, inhibitors

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