NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.
|Source||Oncotarget (2014). Figure 3. NSC 319726|
|Cell Lines||R175H cells|
|Incubation Time||24 h|
|Results||We incubated TOV112D cells with either ZMC1 or NTA and performed immunoprecipitation (IP) experiments with the antibody PAB240, which specifically recognizes misfolded and unfolded p53.|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
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