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NP118809

Cat. No. M3613

NP118809 Structure

Synonym: 39-1B4, NP-118809

Size Price Availability Quantity
10mg USD 160 In stock
50mg USD 480 In stock
100mg USD 720 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

NP-118809 (39-1B4) is a potent N-type calcium channel blockers (IC50= 0.11 uM) which has good selectivity over L-type calcium channels. NP-118809 exhibites increased N-type channel blockade (IC50=0.11 uM) and is 111-fold more selective for N-type channels (L-type calcium channel IC50=12.2 uM). NP118809 further exhibits a number of favorable preclinical characteristics as they relate to overall pharmacokinetics and minimal off-target activity including the hERG potassium channel.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 460.61
Formula C32H32N2O
CAS Number 41332-24-5
Purity >99%
Solubility DMSO
Storage at -20°C
References

Scaffold-based design and synthesis of potent N-type calcium channel blockers.
Zamponi GW, et al. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6467-72. PMID: 19815411.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: NP118809, 39-1B4, NP-118809 supplier, Calcium Channel, inhibitors

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