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Novobiocin Sodium

Cat. No. M5825
Novobiocin Sodium Structure
Synonym:

Albamycin; Cathomycin

Size Price Availability Quantity
100mg USD 100  USD100 In stock
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Quality Control & Documentation
Biological Activity

Novobiocin Sodium is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria.

Chemical Information
Molecular Weight 634.61
Formula C31H35N2O11.Na
CAS Number 1476-53-5
Solubility (25°C) 100 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhao H, et al. Bioorg Med Chem Lett. Novobiocin analogues with second-generation noviose surrogates.

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Keywords: Novobiocin Sodium, Albamycin; Cathomycin supplier, Topoisomerase, inhibitors, activators


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