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Novobiocin Sodium

Cat. No. M5825
Novobiocin Sodium Structure
Synonym:

Albamycin; Cathomycin

Size Price Availability Quantity
100mg USD 100 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Novobiocin Sodium is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 634.61
Formula C31H35N2O11.Na
CAS Number 1476-53-5
Purity >98%
Solubility 100 mg/mL in DMSO
Storage at -20°C
References

Novobiocin analogues with second-generation noviose surrogates.
Zhao H, et al. Bioorg Med Chem Lett. 2013 Jan 15;23(2):552-7. PMID: 23234644.

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  Catalog
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Keywords: Novobiocin Sodium, Albamycin; Cathomycin supplier, Topoisomerase, inhibitors

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