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Norethindrone acetate

Cat. No. M20990
Norethindrone acetate Structure
Synonym:

19-Norethindrone acetate, NA

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Quality Control & Documentation
Biological Activity

Norethindrone acetate (19-Norethindrone acetate, NA) is a common synthetic hormone used in oral contraceptives. Norethindrone acetate is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis.

Chemical Information
Molecular Weight 340.46
Formula C22H28O3
CAS Number 51-98-9
Solubility (25°C) DMSO 68 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yahiya Y Syed. Drugs. Relugolix/Estradiol/Norethisterone (Norethindrone) Acetate: A Review in Symptomatic Uterine Fibroids

[2] No authors listed. Am J Health Syst Pharm. Relugolix, Estradiol, and Norethindrone Acetate

[3] Ayman Al-Hendy, et al. N Engl J Med. Treatment of Uterine Fibroid Symptoms with Relugolix Combination Therapy

[4] Emilia Huvinen, et al. BMJ Sex Reprod Health. Norethisterone and its acetate - what's so special about them?

[5] Colleen L Casey, et al. Clin Interv Aging. HT update: spotlight on estradiol/norethindrone acetate combination therapy

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Keywords: Norethindrone acetate, 19-Norethindrone acetate, NA supplier, Estrogen Receptor, inhibitors, activators


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