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NNC0640

Cat. No. M10144
NNC0640 Structure
Synonym:

NNC-0640

Size Price Availability Quantity
5mg USD 360  USD400 In stock
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

NNC0640 is a potent, negative allosteric modulator (NAM) of human G-protein-coupled glucagon receptor (GCGR) with IC50 of 69.2 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 573.67
Formula C29H31N7O4S
CAS Number 307986-98-7
Purity >98.5%
Solubility DMSO ≥ 100 mg/mL
Storage at -20°C
References

Structure of the full-length glucagon class B G-protein-coupled receptor
Haonan Zhang, et al. Nature. 2017 Jun 8;546(7657):259-264. PMID: 28514451.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: NNC0640, NNC-0640 supplier, Glucagon Receptor, inhibitors

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