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NNC0640

Cat. No. M10144
NNC0640 Structure
Synonym:

NNC-0640

Size Price Availability Quantity
5mg USD 120  USD120 In stock
10mg USD 200  USD200 In stock
25mg USD 360  USD360 In stock
50mg USD 540  USD540 In stock
100mg USD 820  USD820 In stock
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Quality Control & Documentation
Biological Activity

NNC0640 is a potent, negative allosteric modulator (NAM) of human G-protein-coupled glucagon receptor (GCGR) with IC50 of 69.2 nM.

Chemical Information
Molecular Weight 573.67
Formula C29H31N7O4S
CAS Number 307986-98-7
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Haonan Zhang, et al. Nature. Structure of the full-length glucagon class B G-protein-coupled receptor

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Keywords: NNC0640, NNC-0640 supplier, Glucagon Receptor, inhibitors, activators


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