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Nitrendipine

Cat. No. M3455
Nitrendipine Structure
Size Price Availability Quantity
100mg USD 150 In stock
500mg USD 400 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.It is an investigational dihydropyridine calcium-channel antagonist for the treatment of hypertension. Nitrendipine and BRL 38227 cause concentration-related inhibitions of the inositol phosphate response to histamine (100 uM). Similar maximal inhibitions were caused by each agent (55-58%). Inhibitory effect of BRL 38227 was reduced in potency (IC50 = 5.5 uM), but not magnitude, in the presence of glibenclamide (0.5 uM). <

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 360.37
Formula C18H20N2O6
CAS Number 39562-70-4
Purity >99%
Solubility DMSO 70 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Nitrendipine supplier, Calcium Channel, inhibitors

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