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Nitrendipine

Cat. No. M3455
Nitrendipine Structure
Synonym:

BAY-E-5009

Size Price Availability Quantity
50mg USD 70  USD70 In stock
100mg USD 125  USD125 In stock
500mg USD 300  USD300 In stock
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Quality Control & Documentation
Biological Activity

Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.It is an investigational dihydropyridine calcium-channel antagonist for the treatment of hypertension. Nitrendipine and BRL 38227 cause concentration-related inhibitions of the inositol phosphate response to histamine (100 uM). Similar maximal inhibitions were caused by each agent (55-58%). Inhibitory effect of BRL 38227 was reduced in potency (IC50 = 5.5 uM), but not magnitude, in the presence of glibenclamide (0.5 uM). <

Chemical Information
Molecular Weight 360.37
Formula C18H20N2O6
CAS Number 39562-70-4
Solubility (25°C) DMSO 48 mg/mL
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] M Asif A Siddiqui, et al. Fixed-dose combination enalapril/nitrendipine: a review of its use in mild-to-moderate hypertension

[2] K L Goa, et al. Nitrendipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension

[3] A Zanchetti. Nitrendipine and ACE inhibitors

[4] U L Hulthn, et al. Review of long-term trials with nitrendipine

[5] T M Santiago, et al. Nitrendipine: a new dihydropyridine calcium-channel antagonist for the treatment of hypertension

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  Catalog
Abmole Inhibitor Catalog




Keywords: Nitrendipine, BAY-E-5009 supplier, Calcium Channel, inhibitors, activators


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