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Nilvadipine

Cat. No. M3440
Nilvadipine Structure
Synonym:

ARC029, FR34235

Size Price Availability Quantity
50mg USD 220 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Nilvadipine (ARC029) is a potent calcium channel blocker with an IC50 of 0.03 nM. Nilvadipine (ARC029) is used for the treatment of hypertension and chronic major cerebral artery occlusion. Nilvadipine (ARC029) were administrated? intramuscularly in daily doses of 0.01-10 mg/kg for three weeks, starting on the day of cuff-placement. Nilvadipine (ARC029) prvented the cuff-induced intimal thickening in a dose-dependent manner, and was more potent than the other calcium antagonists including nifedipine, diltiazem and verapamil. In an in vitro experiment on inhibition of migration of rat aortic smooth muscle cells, using zymosan-activated air pouch exudate as a chemoattractant in modified Boyden chambers, Nilvadipine (ARC029) was also the most potent among the calcium antagonists tested. The IC50 values were 0.17 nM for nifedipine, 6 nM for verapamil and 0.24 mM for diltiazem. Effects of these drugs on proliferation of rat aortic smooth muscle cells and rabbit platelet aggregation were also examined in vitro. At concentrations less than 10 mM, none of the drugs inhibited proliferation of the smooth muscle cells, and only verapamil inhibited collagen-induced platelet aggregation (IC50 = 0.9 mM).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 385.37
Formula C19H19N3O6
CAS Number 75530-68-6
Purity >99%
Solubility DMSO 70 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Nilvadipine, ARC029, FR34235 supplier, Calcium Channel, inhibitors

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